Pumping Up the Synapse

Pumping Up the Synapse

Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role for the KCC2 pump, also responsible for the GABAergic synapse developmental switch, in regulating spiny excitatory synapse maturation, implicating it in the ...

Building up the inhibitory synapse

“Building up the inhibitory synapse” is a complex phenomenon involving a variety of dynamically regulated molecular and cellular processes whose nature is still largely unknown. Understanding the role of different proteins in controlling synapses formation and stabilization may help elucidating, at the network level, the mechanisms by which inhibitory transmission controls network excitability ...

Single Photon Detection Using Frequency Up-Conversion with Pulse Pumping

In any quantum communication system, such as a quantum key distribution (QKD) system, data rates are mainly limited by the system clock rate and the various link losses. While the transmission clock rate is limited by the temporal resolution of the single-photon detectors, losses in a fiber-based quantum communication system can be minimized by operating in the near infrared range (NIR), at 131...

The End of Pumping?

The thermal and mechanical deformation study of up - stream pumping mechanical seal

Taking the viscosity-temperature relationship of the fluid film into consideration, a 3-D numerical model was established by ANSYS software which can simulate the heat transfer between the upstream pumping mechanical seal stationary and rotational rings and the fluid film between them as well as simulate the thermal deformation, structure deformation and the coupling deformation of them. Accord...